Oligonucleotide primers used in this work. Besides their insulinotropic action, GLP-1 inhibits glucagon secretion in a glucose-dependent manner, thus diminishing postprandial glucose excursions [ 29 ].
The parameters were set as follows: J Fluoresc 12 2— Cardiovasc Res 28, — According to Nefti et al. J Nutr Sci Vitaminol 56, 48— For weight loss, however, DIT-related satiety is even more important.
BBR has obvious effects on lowering the plasma total cholesterol TCtriglyceride TG and low-density lipoprotein cholesterol LDL-C levels, and these effects may be better in some aspects than those achieved when using simvastatin and atorvastatin [ 13 ]. Therefore, the research and development of safe and effective anti-hyperlipidemia drugs are particularly important.
Guo and Q. Satiety hormones There are other possible mechanisms to explain the improvement in satiety with high-protein diets.
CCKs functions include stimulation of pancreatic secretion, gallbladder contraction and intestinal mobility as well as inhibition of gastric emptying [ 38 ]. The latter may be most important in contributing to increased satiety, especially if the diet is high in protein and low in CHOs.
PCA was applied to identify outliers and detect data grouping or separation trends, and it also produced an overview of the data set. Performance parameters were not affected in the subjects, most likely due to the short study period.
High-protein and low-carbohydrate diets promote hepatic gluconeogenesis to maintain plasma glucose levels. The most important ones seem to be i increased energy expenditure, increased concentrations of ii anorexigenic hormones, and iii metabolites such as amino acids and iv altered gluconeogenesis.
Bioorg Med Chem Lett 20, — The n-butanol fraction of the P. Mus musculus, Minimum absolute abundance: In recent years, in addition to its antibacterial effect [ 2 — 5 ], this natural compound has been increasingly studied for its effects against various diseases, including hyperlipidemia [ 6 ], diabetes [ 78 ], and nervous system [ 9 ] and cardiovascular diseases [ 10 — 12 ].
Increased GLP-1 concentrations were also found in men after a high protein breakfast, lunch and dinner [ 50 ]. Since then, an increasing number of studies in numerous different rodent models, cells and patients with hyperlipidemia have been conducted.
Structure-activity analyses of coumarins implicated a double bond at C3-C4 and a methoxy group at C7 as being essential for the cholesterol-lowering activity. Yang, L. Cholecystokinin CCK is a peptide hormone found in the brain and the gastrointestinal tract [ 32 ].
Two statins, atorvastatin and simvastatin, were used as positive controls. The hamsters were anesthetized for the collection of bile and liver samples.
Along these lines, Westerterp-Plantenga [ 26 ] found a significant increase in h satiety in subjects consuming a high-protein diet compared to a high-fat diet. The phosphorylation at threonine Thr on the alpha-subunit of AMPK has been deemed as an index of activation of this kinase which in turn promotes the phosphorylation and inhibition of acetyl-CoA carboxylase ACCa critical enzyme for controlling fatty acid biosynthesis and oxidation .
It is now clear that CCK reduces food intake and meal size and induces satiety [ 34 ] in a variety of mammalian species including rats, rhesus monkeys and humans. Instead, the authors observed an increased production of ketone bodies especially beta-hydroxybutyrate in response to the high-protein diet.
Clin Colon Rectal Surg 4 4— Tetrahedron 64, — Enteroendocrine cells which release GLP-1 and GIP are in direct contact with the gut lumen and by this means seem to be able to sense arrival and passage of nutrients along the gastrointestinal tract.
AMP-activated protein kinase AMPK is another key regulator of lipid metabolism, imposing profound influence on lipid oxidation, synthesis, and storage . As the absorption of casein is slower due to clot formation, 90 min may be too short to make the conclusion of increased satiety.high-fat diet (HFD), OCA showed no effect on plasma TC level or LDL-C levels but caused a small increase in HDL-C (23).
In contrast to the lack of effect in reduction of plasma HDL-C inCited by: 6. Two studies demonstrate that hyperlipidemia (high cholesterol and high triglycerides in the blood) caused by a high-fat diet accelerates heart-transplant rejection in mice. The researchers also.
This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet. Methods and results: Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat.
Hyperlipidemia occurs very often in modern society along with a high calorie intake and is regarded as one of the greatest risk factors for the prevalence of cardiac vascular disease (CVD).
High-fat diet was purchased from Dyets Inc., and the nutrition contents of high-fat diet were similar to those of the regular diet except low carbohydrate and addition of beef tallow. Body weights were measured weekly, and at every other week blood was collected for blood glucose analysis.
At the end of the study, blood was also collected for determination of plasma insulin and lipid levels Cited by: cholesterol transport (RCT) (22), which is a mechanism of Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet JIANBO HUANG1.